About Bio-Works

Bio-Works carries out R&D, manufacturing and supply of agarose-based resins used to separate proteins and other biomolecules. In this large and well-established area, our products stand out as innovative and cutting edge with exceptional performance. They are used in academic research laboratories, biopharmaceutical companies and many more areas. Our staff are rich in experience within the life science industry and specialized in resins for separation and purification.

Bio-Works research, development and production facilities are located in Uppsala, Sweden at Klövern Business Park, in the heart of an area well known worldwide for chromatography and separation technology. All products are manufactured in a pharmaceutical GMP plant.

From Stockholm to Uppsala

Since 2006, Bio-Works has helped customers with the separation of biomolecules. The company was founded in Stockholm. Today, our site for production, research and sales is located in Fyrislund, Uppsala, a place strongly associated with chromatography.

From Uppsala to the rest of the world

Although our site is in Uppsala – we work with customers all over the globe, developing and manufacturing agarose-based solutions for purification of peptides, enzymes, antibodies, and other bio-molecules.

Patented manufacturing method

Our “next generation resins,” WorkBeads,™ vary in agarose content, size range of beads and pore size. Through our patented manufacturing process we are able to offer high quality agarose-based resins that allow our customers to lower their total production costs.

Diversified product portfolio

You can find optimized products for purification in several categories such as size exclusion, ion exchange and affinity purification. From small lab samples to industrial scale production. Our resins are available in bulk– or in pre-packed disposable or glass columns ready for connection to your chromatography system.

Environmental focus

Bio-Works actively works with sustainable development and we run projects continuously to improve the environmental impact of production. We put great focus on providing our customers with outstanding service and assistance with research projects, manufacturing and technical service.

Solid team

Bio-Works was founded by four leaders in protein purification and many of us have worked for Pharmacia and GE Healthcare. We have as much passion for protein purification as we have experience in this field. We actively promote equality, in a dynamic, multi-national team with a range of skills. We believe the best recipe for great service is a mixture of innovative thinking and long experience!

Our technology

Proteins for example, but also many other biomolecules, can be purified from complex mixtures in sample solutions using liquid chromatography. Small beads of a highly rigid adsorber beads (made of agarose) are packed into a column. The beads are designed to selectively bind the protein under specific chemical conditions. The sample solution is pumped through the column, and the protein of interest binds to the beads. The rest of the sample is washed through the column. To then recover the protein, a solution of different pH or ionic strength is passed through the column. The protein releases from the bead and is washed from the column and collected.

A similar approach is used to separate molecules based on size in which the physical structure of the beads allows certain sized molecules to pass through or be retained by the column. The beads can also be coated with various substances which will specifically bind a molecule of interest, allowing it to be separated from other molecules and purified or concentrated.

Agarose used as starting material is an inert, versatile, low cost and readily available natural material. It will not denature or in any other way harm the delicate biotechnology products that are purified. Agarose media is fundamental to bio-separations and widely used in this area. Specialist knowledge is required to produce beads with suitable size, rigidity and porosity and to further modify them so the target molecule will bind in the capture process.

WorkBeads™, BabyBio™ and OptioBio™ are trademarks of Bio-Works Technologies AB. All other trademarks are the property of their respective owners. Products and technologies from Bio-Works Technologies AB are proprietary, patented or patent pending. All infringements are prohibited and may be prosecuted.