Applications
Oligonucleotides
WorkBeads 40Q anion exchange resin has a high binding capacity for producing pure oligonucleotides
The purity of custom-made oligonucleotide preparations produced by solid-phase synthesis can be very high but purification is often required to remove incomplete or erroneous sequences. Anion exchange chromatography is an attractive choice since it can separate the negatively charged oligonucleotides based on length. For these purifications WorkBeads 40Q has proven to be a superior chromatography resin giving high binding capacity and pure oligonucleotides.

Download technical documents and examples
Poster
Effects of elution conditions in the purification of oligonucleotides by agarose-based anion exchange chromatography
Poster
Important optimization parameters for AIEX purifications of 45 nt-long RNA molecules
Whitepaper
WorkBeads 40/100 SEC can be used to desalt oligonucleotides and can be cleaned with 1 M NaOH
Application note
Optimization of AIEX purification parameters for phosphorothioate oligonucleotides