Discover how WorkBeads 40Q anion exchange resin is a cost-effective and reproducible purification method that has a high binding capacity for producing pure oligonucleotides.
The purity of custom-made oligonucleotide preparations produced by solid-phase synthesis can be very high but purification is often required to remove incomplete or erroneous sequences. Anion exchange chromatography is an attractive choice since it can separate the negatively charged oligonucleotides based on length.
For these purifications (including siRNA and mRNA), WorkBeads 40Q has proven to be a superior chromatography resin giving high binding capacity and highly pure oligonucleotides.
Download technical documents and examples
Poster
Optimization and scale-up of oligonucleotide purifications
