WorkBeads TREN

WorkBeads™ 40 TREN resin for multimodal Ion Exchange Chromatography (IEX) has a ligand that is positively charged below approx. pH 9. The resin can be used for several different applications, e.g., for multimodal IEX, for sample cleanup in monoclonal antibody (mAb) purification processes in order to guard the Protein A column from chromatins and other host cell impurities, or as a polishing step in the mAb purification process.

  • Improved selectivities through multimodal IEX separation
  • Reduced fouling of Protein A resins by chromatin and host cell impurity removal
  • High binding capacity and purity


WorkBeads 40 TREN resin contains ligands based on Tris(2-aminoethyl)amine (TAEA). The structure of the ligand used in WorkBeads 40 TREN is shown in Figure 1. WorkBeads 40 TREN resin can be used for the separation of biomolecules exploiting surface charge to purify proteins, peptides and oligonucleotides. It can also be used in flow through mode to adsorb impurities while letting the target pass through the column (negative chromatography mode).

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