Bio-Works Scale-up Calculator
HTML-version af den uploadede Excel-calculator. Den matcher Excel-logikken i workbooken for Bind-elute og Flow-through.
Step 1
Lab scale experiment
Dynamic Binding Capacity (Qbx)
mg/mL
Bed height
cm
Column diameter
mm
Lab-scale flow rate
mL/min
Step 2
Scale-up parameters
Bed height
cm
Total mass of target molecule
g
Desired safety factor
%
Step 3
Practical scale-up plan
Fill either volume or diameter
L
Fill either diameter or volume
mm
Fill in only one of the two fields: column volume or column diameter.
Calculated values
Lab scale calculations
vlab
cm/h
tlab
min
Vlab
mL
Theoretical
Scale-up calculations
Min. resin vol
L
dprocess
mm
vprocess
cm/h
qprocess
L/h
Final result
Practical implementation
Vprocess
L
dprocess
mm
hprocess
cm
tprocess
min
qprocess
L/h
vprocess
cm/h
Safety factor
%
Step 1
Lab scale experiment
Load volume
mL
Bed height
cm
Column diameter
mm
Lab-scale flow rate
mL/min
Step 2
Scale-up parameters
Bed height
cm
Total volume of load
L
Desired safety factor
%
Step 3
Practical scale-up plan
Fill either volume or diameter
L
Fill either diameter or volume
mm
Fill in only one of the two fields: column volume or column diameter.
Calculated values
Lab scale calculations
Vlab
mL
vlab
cm/h
tlab
min
Tprocess
min
Theoretical
Scale-up calculations
Min. resin vol
L
dprocess
mm
vprocess
cm/h
qprocess
L/h
Final result
Practical implementation
Vprocess
L
dprocess
mm
hprocess
cm
tprocess
min
qprocess
L/h
vprocess
cm/h
Safety factor
%
